Recent advance in role of lipid peroxidation-mediated ferroptosis in Parkinson's disease
10.3760/cma.j.cn115354-20250616-00349
- VernacularTitle:脂质过氧化介导铁死亡在帕金森病中的作用研究进展
- Author:
Shiyuan LIN
1
;
Meiting ZHANG
;
Xinying GAO
;
Qiongna CHEN
;
Xuanhao LIN
;
Wanli HUANG
;
Chunnuan CHEN
Author Information
1. 福建医科大学第二临床医学院，泉州 362000
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Ferroptosis;
Lipid peroxidation;
Iron metabolism disorder;
Signaling pathway;
Therapeutic strategy
- From:
Chinese Journal of Neuromedicine
2025;24(11):1154-1161
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has been recently identified as a key role in Parkinson's disease (PD) pathogenesis. In particular, lipid peroxidation-mediated ferroptosis is considered a key event leading to the death of dopaminergic neurons. This article reviews the role of lipid peroxidation-mediated ferroptosis in PD and its involved key signaling pathways, and explores the related targeted therapeutic strategies, with the aim of providing new ideas for targeted treatment of PD.
