Brain age study in patients with prolonged disorders of consciousness based on amplitude of low frequency fluctuation in resting-state functional resonance imaging
10.3760/cma.j.cn115354-20250124-00046
- VernacularTitle:基于静息态功能磁共振成像低频振幅的慢性意识障碍患者脑龄研究
- Author:
Sixun WANG
1
;
Qiuyou XIE
;
Qimei LIANG
;
Haili ZHONG
;
Xiyan HUANG
;
Simin YE
;
Jing HUANG
Author Information
1. 南方医科大学生物医学工程学院，广东省医学图像处理重点实验室，广东省医学成像与诊断技术工程实验室，广州 510515
- Publication Type:Journal Article
- Keywords:
Prolonged disorders of consciousness;
Brain age;
Brain age gap;
Resting-state functional magnetic resonance imaging;
Amplitude of low frequency fluctuatio
- From:
Chinese Journal of Neuromedicine
2025;24(5):449-455
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the differences in brain age and brain age gap (BAG) between patients with prolonged disorders of consciousness (pDoC) and healthy controls (HC).Methods:A retrospective cross-sectional study was performed; 43 patients with pDoC admitted to Rehabilitation Medicine Center, Zhujiang Hospital, Southern Medical University from January 2020 to October 2022 were enrolled; 26 healthy volunteers recruited at the same time and 187 healthy subjects from the publicly available healthy control dataset Nathan Kline Institute-Rockland Sample (NKI-RS) were chosen as HC group. The clinical and imaging data of these subjects were collected. A brain age estimation model was constructed based on amplitude of low-frequency fluctuation (ALFF) in resting-state functional magnetic resonance imaging (rs-fMRI) for healthy individuals, and the pDoC group was used as the test set. A two-sample t-test was used to compare the brain age and BAG differences between the pDoC group and HC group. Pearson correlation analysis was used to explore the correlation between BAG and coma recovery scale-revised (CRS-R) in the pDoC group. Results:The chronological age and estimated brain age in the HC group were (41.54±9.61) and (42.32±10.65) years, respectively, without significant difference ( t=-0.254, P=0.801). The chronological age and estimated brain age in the pDoC group were (49.91±12.03) and (62.79±15.00) years, respectively, with significant difference ( t=-4.341, P<0.001). The BAG in the HC and pDoC groups were (0.78±4.59) and (12.88±7.17) years, respectively, with significant difference ( t=-7.822, P<0.001). Correlation analysis results showed that in the pDoC patients, no correlation was noted between BAG and CRS-R score on the day of imaging scan or 6 months after the day of imaging scan ( r=0.090, P=0.738; r=0.205, P=0.674); no correlation was noted between BAG and difference in CRS-R score (difference value of CRS-R score 6 months after the day of imaging scan-CRS-R score on the day of imaging scan, r=0.246, P=0.687). Conclusion:Compared with the HC subjects, patients with pDoC exhibit an abnormal increase in brain age, suggesting that pDoC caused by severe brain injury may lead to accelerated brain aging.
