Recent advances in activation mechanisms of A1 and A2 astrocytes and their relationships with different CNS diseases

VernacularTitle:A1、A2型星形胶质细胞活化机制及其与中枢神经系统疾病关系的研究进展
Author: Longyun ZHOU ¹ ; Shufen LIU ; Xiao LU
Author Information

1. 南京医科大学第一附属医院康复医学中心，南京　210029
Publication Type:Journal Article
Keywords: Astrocyte; Cell activation; Stroke; Alzheimer's disease; Parkinson's disease; Central nervous system
From: Chinese Journal of Neuromedicine 2025;24(4):407-414
CountryChina
Language:Chinese
Abstract: Astrocytes are the most important glial cell type in the central nervous system (CNS), which play an important role in maintaining homeostasis, regulating synaptic plasticity and protecting neurons. During pathological damage, astrocytes can differentiate into A1 and A2 subtypes, which play a dual role in blocking or repairing nerve damage and participate in the pathological changes of a variety of CNS diseases such as stroke, Alzheimer's disease, Parkinson's disease, spinal cord injury and cervical spondylotic myelopathy. This review focuses on the phenotype characteristics and activation mechanisms of A1 and A2 astrocytes and their relationships with different CNS diseases, in order to provide reference for treatment of CNS diseases.