Logistic regression analysis of shear wave elastography combined with thyroglobulin antibody in the diagnosis of thyroid nodules in pilots
10.3760/cma.j.cn113854-20221220-00152
- VernacularTitle:剪切波弹性成像联合甲状腺球蛋白抗体诊断飞行员甲状腺结节Logistic回归分析
- Author:
Yingkun XIE
1
;
Rui HAN
;
Xiaohui ZHENG
;
Qiaolian ZHANG
;
Weibo SHI
;
Yuhui ZHU
Author Information
1. 联勤保障部队第九六〇医院特诊科，济南 250031
- Publication Type:Journal Article
- Keywords:
Thyroid nodules;
Thyroglobulin;
Antibodies;
Ultrasonography;
Logistic model;
Pilots
- From:
Chinese Journal of Aerospace Medicine
2023;34(3):137-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the value of conventional ultrasound, shear wave elastography and thyroglobulin antibody in the differential diagnosis of benign and malignant thyroid nodules in pilots by Logistic regression model.Methods:The cohort study was used. The clinical data of pilots with thyroid nodules who were admitted to the 960th Hospital of the Joint Logistics Support Force from January of 2010 to May of 2022 were collected, including thyroglobulin antibody results and ultrasound images. The pathological results were used as the gold standard to establish a binary Logistic regression model and evaluate its ability to predict benign and malignant nodules.Results:Seventy-two pilots were included, all were male, with 22-55 years old and 75-5 600 h flying hours. A total of 85 nodules were detected. Among them, 48 nodules were benign nodules, including 34 nodular goiters, 10 adenomas, and 4 thyroid cystic nodules. There were 37 malignant nodules, all of which were papillary carcinomas. A total of 4 statistically significant characteristic variables were screened out, including thyroid nodule morphology, microcalcification, serum thyroglobulin antibody, and maximum elastic modulus. The sensitivity, specificity and accuracy of Logistic regression model in predicting benign and malignant thyroid nodules was 83.9%, 79.6% and 81.5%, respectively. The area under the receiver operating characteristic curve was 0.908 (95% CI: 0.850-0.966). Conclusions:The Logistic regression model established by shear wave elastography combined with thyroglobulin antibody has high diagnostic value. It is helpful to the differential diagnosis of benign and malignant thyroid nodules in pilots.
