Recent advance in TDP-43 pathology in diagnosis and treatment of amyotrophic lateral sclerosis
10.3760/cma.j.cn115354-20241008-00620
- VernacularTitle:病理性TDP-43蛋白在肌萎缩侧索硬化诊疗中的研究进展
- Author:
Shiyu SHI
1
;
Yu ZHANG
1
;
Yaxi LIU
1
;
Qi NIU
1
Author Information
1. 南京医科大学第一附属医院罕见病医学科，南京 210029
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
TAR DNA binding protein-43;
Diagnosis;
Treatment
- From:
Chinese Journal of Neuromedicine
2025;24(3):304-309
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects upper and lower motor neurons, and its mechanism has not been fully elucidated. In recent years, studies have shown that TAR DNA binding protein-43 (TDP-43) can affect neuronal function through multiple pathways and is closely related to the clinical manifestations and prognoses of ALS patients, suggesting that TDP-43 pathology may be an important target for the diagnosis and treatment of ALS. This article reviews the research progress on role of TDP-43 pathology in pathological mechanism of ALS and its application in diagnosis and treatment of ALS, aiming to provide reference for diagnosis and treatment of ALS.
