Characteristics of β and γ oscillations in the subthalamic nucleus of Parkinson's disease patients with dyskinesia
10.3760/cma.j.cn115354-20240913-00568
- VernacularTitle:帕金森病患者异动症状态下丘脑底核β、γ振荡特征研究
- Author:
Baojian ZHANG
1
;
Pengfei WANG
;
Han LIU
;
Yourang ZHAO
;
Weifeng LU
;
Yuming XU
Author Information
1. 郑州大学第一附属医院神经外科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Levodopa-induced dyskinesia;
Subthalamic nucleus;
β oscillation;
γ oscillation
- From:
Chinese Journal of Neuromedicine
2025;24(3):243-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of β and γ oscillations in Parkinson's disease (PD) patients with levodopa-induced dyskinesia (LID).Methods:Seventeen patients with advanced idiopathic PD received subthalamic nucleus deep brain stimulation (STN-DBS) from August 2019 to June 2021 at Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University were enrolled; 11 patients were without LID before surgery (PD group) and 6 patients were with LID before surgery (LID group). Preoperative electrophysiological data of the STN, including Area under power spectral density (PSD-AUC), burst amplitude and duration of β and γ oscillations, were compared between the two groups.Results:PSD-AUC of β oscillation at 25-35 Hz in the PD group (60.39±1.00) was significantly increased compared with that in the LID group (54.33±0.55), whereas the PSD-AUC of γ oscillation at 65-85 Hz in the LID group (97.31±1.84) was significantly increased compared with that in the PD group (41.52±7.42, P<0.05). The aburst mplitude and duration of β oscillation in the PD group were significantly increased compared with those in the LID group ([8.52±1.00] au] vs. [1.09±0.13] au, [13 344±2 069] ms vs. [1 442±128] ms, P<0.05), while the burst amplitude and duration of γ oscillation in the LID group were significantly higher than those in the PD group ([5.03±0.55] au vs. [0.14±0.01] au, [12 276±5 011] ms vs. [1 741±233] ms, P<0.05). Conclusion:The imbalance of β-γ oscillations in the STN is associated with LID pathophysiology.
