Recent advance in role of metabolism reprogramming of microglia in Alzheimer's disease

VernacularTitle:小胶质细胞代谢重编程在阿尔茨海默病中的作用研究进展
Author: Jie WANG ¹ ; Xiaoting ZHU ; Yunqiang LI ; Xinyue ZHANG ; Fan LI ; Mingquan LI
Author Information

1. 长春中医药大学中西医结合学院，长春　130117
Publication Type:Journal Article
Keywords: Alzheimer's disease; Microglia; Metabolic reprogramming; Mechanism
From: Chinese Journal of Neuromedicine 2025;24(4):401-406
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment, memory decline and emotional loss, which is more common in middle-aged and elderly people. In recent years, studies have shown that chronic neuroinflammation is an important factor leading to AD development. As the core participant in neuroinflammation, microglia play a dual role in the pathological process of AD: on one hand, through M1 polarization, they exert a pro-inflammatory effect and exacerbate the neurotoxic response; on the other hand, through M2 polarization, they enhance the phagocytic ability of amyloid β-protein and exert a neuroprotective effect. Metabolic reprogramming is the key in determining the polarization of microglia M1/M2 type and exerting neurotoxicity/protection. Therefore, this article reviews the recent advance in role of metabolism reprogramming of microglia in AD, in order to provide new idea and direction for studing AD pathogenesis and treatment in the future.