Recent advance in microglia-astrocyte crosstalk in neurodegenerative diseases
- VernacularTitle:小胶质细胞-星形胶质细胞串扰在神经退行性疾病中的研究进展
- Author:
Yihao LI
1
;
Yuxin CHEN
1
;
Xiaorui LIU
1
;
Mengyang FAN
1
;
Liuqing XU
1
;
Peiyuan ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Neurodegenerative disease; Microglia; Astrocyte; Crosstalk
- From: Chinese Journal of Neuromedicine 2025;24(1):82-87
- CountryChina
- Language:Chinese
- Abstract: Astrocytes and microglia engage in extensive and complex communication and mutual effect, which referrs to microglia-astrocyte crosstalk. Recent studies have highlighted that this crosstalk plays a pivotal role in neurodegenerative diseases, exerting either protective or detrimental effects. This review briefly introduces the molecular mechanism of microglia-astrocyte crosstalk and its research progress in Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Parkinson's disease, aiming to provide new research directions and therapeutic targets for clinical improvement of neurodegenerative diseases from perspective of microglia-astrocyte crosstalk.
