Safety and efficacy of intrasaccular flow disruptor in intracranial aneurysms
10.3760/cma.j.cn115354-20241216-00790
- VernacularTitle:瘤内扰流装置治疗颅内动脉瘤的安全性及有效性分析
- Author:
Jifa LIU
1
;
Yuanzhi LI
1
;
Feng FAN
1
;
Hang ZHANG
1
;
Nan MA
1
;
Zhen WANG
1
;
Sheng GUAN
1
Author Information
1. 郑州大学第一附属医院神经介入科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Intrasaccular flow disruptor;
Intracranial aneurysm;
Interventional therapy;
Efficacy;
Safety
- From:
Chinese Journal of Neuromedicine
2025;24(3):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the safety and efficacy of intrasaccular flow disruptor in intracranial aneurysms, including wide-necked aneurysms.Methods:A retrospective analysis was performed; 102 patients with intracranial aneurysms treated with intrasaccular flow disruptor at Department of Neurointervention, First Affiliated Hospital of Zhengzhou University from August 2022 to November 2024 were enrolled; their clinical and imaging data were collected. The aneurysm characteristics and perioperative complications were summarized; aneurysm occlusion was evaluated by Woven EndoBridge occlusion scale (WOS) immediately after surgery and during the follow-up period.Results:Among the 102 aneurysms, 33 were anterior cerebral artery aneurysms, 40 were middle cerebral artery aneurysms, 17 were internal carotid artery aneurysms and 12 were basilar artery aneurysms; 73 aneurysms were regular intracranial saccular aneurysms and 29 were irregular saccular ones (17 of them with daughter sacs); 12 aneurysms were ruptured at acute phase. The surgical success rate was 100%: single intrasaccular flow disruptor was implanted into 95 patients, and stent-assisted or salvage treatments were given to 7 patients). Immediately after surgery, WOS grading A was noted in 5 patients, grading B in 7, grading C in 31, and grading D in 59. Two patients suffered severe perioperative complications and passed away: one patient died for ischemic complications that ensued after stent salvage treatment (parent artery being compressed by intrasaccular flow disruptor); the other patient died for hemorrhagic complications triggered by rupture of an initially unruptured aneurysm following intrasaccular flow disruptor implantation. Among them, 52 patients completed postoperative DSA follow-up, with a median follow-up of 205 (168, 292) days; WOS grading A was noted in 31 patients, grading B in 9, grading C in 8, and grading D in 4 at the last follow-up; the full occlusion rate was 92.3%, and no ischemic or hemorrhagic adverse events occurred.Conclusion:Intrasaccular flow disruptor shows high short-term safety and good efficacy in the treatment of intracranial aneurysms.
