Changes in astrocyte microenvironment in demyelinating lesions
10.3760/cma.j.cn115354-20241008-00615
- VernacularTitle:脱髓鞘病变中星形胶质细胞周围微环境的变化
- Author:
Xiaoling SHANG
1
;
Yuqiu CHEN
1
Author Information
1. 长春中医药大学基础医学院，长春 130117
- Publication Type:Journal Article
- Keywords:
Demyelination;
Astrocyte;
Microenvironment;
Exosome;
Regional heterogeneity;
Gut microbiota
- From:
Chinese Journal of Neuromedicine
2024;23(12):1272-1278
- CountryChina
- Language:Chinese
-
Abstract:
Astrocyte is the main type of glial cells in the central nervous system, maintaining its synaptic homeostasis through uptake and recovery of neurotransmitters, supply of energy substances, synthesis of lipids, and release of glial transmitters. The transition from resting astrocyte to reactive astrocyte is a node of inflammatory pathogenesis and a common feature of many demyelinating diseases. In demyelinating lesions, these functions of the astrocyte vary with changes in the cellular microenvironment. In this study, we investigate the dynamic changes of astrocyte microenvironment in demyelinating lesions, such as cholesterol secretion, extracellular matrix deposition, exosome regulation, cytotoxic substance secretion and gut microbiota interference, and its effect on AS, so as to provide evidences for treatment of demyelinating lesions.
