Neuroimaging study on shared and distinct subcortical nuclei volume alterations underlying neuropsychiatric symptoms in Parkinson′s disease
10.3760/cma.j.cn113661-20250127-00043
- VernacularTitle:帕金森病相关神经精神症状共性与特异性皮质下核团体积改变的影像学研究
- Author:
Zhengjing SHEN
1
;
Huijuan MA
1
;
Zonghui CHEN
1
;
Qianling LU
1
Author Information
1. 南京医科大学附属逸夫医院神经内科，南京 211000
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Parkinson′s disease;
Neuropsychiatric symptoms;
Subcortical nuclei volume alterations pattern
- From:
Chinese Journal of Psychiatry
2025;58(12):925-934
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to evaluate the subcortical structural alteration patterns associated with five distinct neuropsychiatric symptoms (NPS) associated with Parkinson′s disease and provide macroscopic brain structural evidence to further explore their underlying pathophysiological mechanism.Methods:Clinical data and 3D-T 1 weighted images from 505 patients with Parkinson′s disease and 167 age-and sex-matched healthy controls were obtained from the Parkinson′s Progression Markers Initiative database (July 2010-August 2022). The subcortical nucleus volumes of the overall NPS patient group, as well as subgroups of patients with specific NPS subtypes (depression, anxiety, apathy, impulsive-compulsive behaviors (ICBs), and hallucinations), were measured and compared to those of healthy controls through mixed-effects models. Spatial similarity analysis and hierarchical clustering analysis of subcortical volume alteration patterns were employed to investigate the commonalities and specificities of subcortical damage in NPS. Results:NPS patients exhibited widespread subcortical atrophy, primarily concentrated in the bilateral putamen, bilateral hippocampus, and left amygdala (Cohen′s d=-0.38--0.12, FDR P<0.05). Subgroup analysis revealed that anxiety and depression were associated with gray matter atrophy in the bilateral putamen and amygdala (Cohen′s d=-0.73--0.32, FDR P<0.05), while apathy, hallucinations, and ICBs were linked to atrophy in the bilateral putamen, bilateral amygdala, and bilateral hippocampus (Cohen′s d=-0.61--0.11, FDR P<0.05,Cohen′s d=-0.43--0.36, P<0.05). Similarity and clustering analyses demonstrated high spatial correlation between anxiety and depression ( r=0.83, P<0.01), forming one cluster, whereas apathy, hallucinations, and ICBs formed another distinct cluster. Conclusion:NPS in Parkinson′s disease exhibit both commonalities and specificities. Apathy, hallucinations, and ICBs are associated with more severe subcortical damage patterns. These findings may provide new insights into the pathophysiology and progression of Parkinson′s disease.
