The potential, progress, and challenges of temporal interference transcranial electrical stimulation in the treatment of psychiatric disorders
10.3760/cma.j.cn113661-20250331-00152
- VernacularTitle:时间干涉经颅电刺激治疗精神疾病的潜力、进展与挑战
- Author:
Yongxi ZHANG
1
;
Ke LIU
1
;
Zhenxiang ZANG
1
;
Pengfei WANG
1
;
Gang WANG
1
;
Zhi YANG
1
Author Information
1. 首都医科大学附属北京安定医院 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室，北京 100088
- Publication Type:Journal Article
- Keywords:
Electric stimulation;
Temporal interference stimulation;
Psychiatric disorder treatment;
Non-invasive brain modulation;
Deep brain modulation;
Neuromodulat
- From:
Chinese Journal of Psychiatry
2025;58(12):883-890
- CountryChina
- Language:Chinese
-
Abstract:
The functional modulation of deep brain structures plays a crucial role in the treatment of psychiatric disorders; however, current approaches primarily rely on invasive techniques such as deep brain stimulation. Temporal Interference (TI) transcranial electrical stimulation is an emerging non-invasive neuromodulation technique capable of precisely regulating the activity of deep brain nuclei, offering an innovative and promising approach for psychiatric disorder treatment. In recent years, studies conducted on healthy individuals and patients with neurological disorders (e.g., Parkinson's disease) have provided preliminary evidence supporting the deep brain modulation capabilities of TI. Meanwhile, multiple registered clinical studies are actively investigating its potential applications in psychiatric treatment. This review systematically summarizes the fundamental principles, neuromodulatory mechanisms, and recent research advances of TI in psychiatric disorders. Additionally, it highlights key scientific issues that need to be addressed to facilitate further basic research and clinical translation in this field.
