Research progress on endosomes in neurodevelopmental disorders and neurodegenerative diseases
10.3760/cma.j.cn113661-20250213-00065
- VernacularTitle:内体在神经发育障碍与神经变性疾病中的研究进展
- Author:
Ningxia ZHANG
1
;
Liting XUE
1
;
Hongen WEI
1
Author Information
1. 山西医科大学附属山西省人民医院神经内科 脑疾病防治山西省重点实验室，太原030012
- Publication Type:Journal Article
- Keywords:
Endosome;
Autism spectrum disorder;
Schizophrenia;
Alzheimer′s disease;
Parkinson′s disease
- From:
Chinese Journal of Psychiatry
2025;58(10):782-792
- CountryChina
- Language:Chinese
-
Abstract:
Endosomes are organelles in intracellular trafficking, signal transduction, and metabolic regulation. Their dysfunctions are closely related to the pathogenesis of neurodevelopmental disorders (i.e., autism spectrum disorder and schizophrenia) and neurodegenerative diseases (i.e., Alzheimer′s disease, Parkinson′s disease, and Huntington′s disease). This review systematically summarizes advances in understanding endosomal dysfunction across these two categories of diseases. In neurodevelopmental disorders, dysregulated endosome-mediated sorting and recycling of membrane receptors may disrupt synaptic plasticity and neuronal network development. In neurodegenerative diseases, impaired endosomal acidification, trafficking dysfunction, and disrupted crosstalk with the lysosomal system exacerbate the pathological accumulation of toxic proteins, such as β-amyloid and hyperphosphorylated tau. Emerging evidence further suggests that genetic mutations or aberrant expression of endosome-related genes may represent a shared molecular mechanism underlying both disease categories. Future research should focus on deciphering the spatiotemporally dynamic regulatory networks of endosomes and elucidating their heterogeneous roles in neurodevelopmental and neurodegenerative contexts, aiming to provide a theoretical foundation for developing diagnostic biomarkers and targeted therapeutic strategies.
