The bahavioral and electroencephalographic characteristics of impaired cognitive flexibility in OCD patients with comorbid obsessive-compulsive personality disorder
10.3760/cma.j.cn113661-20240709-00222
- VernacularTitle:共病强迫型人格障碍的强迫症患者认知灵活性受损的行为学与脑电特征分析
- Author:
Feng LI
1
;
Gangqin XIONG
;
Haozhe WANG
;
Ming CHENG
;
Daxing WU
;
Mingtian ZHONG
Author Information
1. 华南师范大学脑认知与教育科学教育部重点实验室 华南师范大学心理应用研究中心 心理学院 心理健康与认知科学广东重点实验室，广州510631
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Obsessive-compulsive personality disorder;
Cognitive flexibility;
Task Switch paradigm;
Event-related potentials
- From:
Chinese Journal of Psychiatry
2025;58(4):259-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study was to explore the behavioral and electroencephalographic characteristics of impaired cognitive flexibility in patients with obsessive-compulsive disorder (OCD) with comorbid obsessive-compulsive personality disorder(OCPD).Methods:A cross-sectional study was designed to collect data prospectively from OCD patients who visited the psychology departments at two top-tier hospitals in Changsha between September 2019 and December 2021. The study included 31 patients with OCD+OCPD(18 males, 13 females; aged 15-46 (22.8±8.4) years) and 39 patients with OCD only(25 males, 14 females; aged 15-34 (21.6±4.2) years). Additionally, 32 age-matched healthy controls(HC: 18 males, 14 females; aged 18-25 (20.8±1.7) years). All participants completed the Task-Switching paradigm while behaioral and event-related potentials(ERPs) were recorded simultaneously. Repeated measures analysis of variance was used to compare the group differences in behavioral and ERP data(electrode sites: FZ, FCZ, CZ, PZ; ERP components: amplitude and latency of P2, N2, and P3).Results:The reaction times in both the comorbid and OCD groups were significantly longer than those in the healthy control group ((1 182±287) ms and (1 119±194) ms vs. (886±95) ms; F=18.48, both P<0.001). Accuracy rates in the comorbid and OCD groups were also significantly lower than in the healthy control group ((77±14)% and (77±13)% vs. (84±7)%; F=4.00, both P<0.05). In the task-switching condition, the N2 latency at the CZ electrode was significantly shorter in the comorbid and OCD groups compared to the healthy control group ((290±22) ms and (291±29) ms vs. (308±27) ms; F=3.81, both P<0.05). Furthermore, at the FZ and FCZ electrodes, the N2 latency in the comorbid group was significantly shorter in the switching task compared to the repetition task. Conclusion:OCD patients with comorbid OCPD show more severe cognitive flexibility impairments and display abnormal electrophysiological patterns.
