The role of immunological factors in the pathogenesis of obsessive-compulsive disorder: current status and future perspectives
10.3760/cma.j.cn113661-20241106-00363
- VernacularTitle:免疫学因素在强迫症发病机制中的作用：现状与展望
- Author:
Tingyue BAI
1
;
Yingdan ZHANG
1
;
Dongdong SHI
1
;
Yang WANG
1
;
Zhen WANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心，上海 200030
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Immunity;
Inflammation;
Infection;
Autoimmunity
- From:
Chinese Journal of Psychiatry
2025;58(4):243-249
- CountryChina
- Language:Chinese
-
Abstract:
Obsessive-compulsive disorder (OCD) is a chronic, disabling mental disorder characterized by distressing and intrusive thoughts (obsessions) and/or repetitive or ritualized behaviors (compulsions), which has a multi-factorial pathogenesis. Recent studies suggest that immune dysregulation is present in OCD patients. Since the immune system plays a crucial role in maintaining central nervous system homeostasis, its dysfunction may be a key factor in the pathogenesis of OCD. This article reviews the current research on the immunological pathogenesis of OCD and explores future research directions, aiming to provide insights into the etiology, subtyping and treatment.
