Research progress on the role of polygenic risk scores and gene-environment interactions in the risk and recognition of depression

VernacularTitle:抑郁症多基因风险评分及其与环境因素的相互作用在抑郁症研究中的进展
Author: Rui LIU ¹ ; Yongqi SHAO ; Yufan CAI ; Wenji CHEN ; Zhi XU
Author Information

1. 东南大学附属中大医院心身医学科，南京　210009
Publication Type:Journal Article
Keywords: Depressive disorder; Polygenic risk score; Gene-environment interaction
From: Chinese Journal of Psychiatry 2025;58(3):232-237
CountryChina
Language:Chinese
Abstract: Depression is a psychological disorder that imposes a tremendous social burden, with a high prevalence in China. In recent years, the number of diagnosed cases of depression in China has steadily increased, yet the recognition rate of the disease remains low. Depression demostrates a clear familial aggregation pattern. To improve its recognition, numberous studies have utilized the polygenic risk score for major depressive disorder (MDD-PRS) as a potential genetic marker to identify high-risk populations. This article reviews the latest progress and research on the use of MDD-PRS in depression, aiming to clarify its capacity to capture genetic variations associated with depression, its interaction with environmental factors, and their relationship to the onset of the disorder. Additionally, this review evaluates the predictive performance of existing risk models for depression and proposes potential directions for future research.