Progress in proteomics of schizophrenia based on peripheral blood

VernacularTitle:基于外周血的精神分裂症蛋白质组学研究进展
Author: Lige GE ¹ ; Feifei WANG ¹ ; Zhen MAO ¹ ; Xinke SHI ¹ ; Lu WANG ¹ ; Yushen DING ¹ ; Chuanyue WANG ¹ ; Fang DONG ¹
Author Information

1. 首都医科大学附属北京安定医院　国家精神心理疾病临床医学研究中心　精神疾病诊断与治疗北京市重点实验室　北京脑重大疾病研究院精神分裂症研究所，北京　100088；首都医科大学人脑保护高精尖创新中心，北京　100069
Publication Type:Journal Article
Keywords: Schizophrenia; Proteomic; Peripheral blood; Biomarker
From: Chinese Journal of Psychiatry 2025;58(3):224-231
CountryChina
Language:Chinese
Abstract: Schizophrenia is a debilitating mental disorder with complex etiology. Early identification of high-risk individuals and early intervention for early-stage patients can help improve prognosis, but effective identification methods are lacking. In recent years, research on proteomic techniques based on peripheral blood has achieved certain advancements in exploring the etiology of schizophrenia, as well as in early recognition and diagnostic modeling. This paper provides a review of the research methodologies of peripheral blood-based proteomics and the candidate biomarkers identified through these method.