Alteration of static and dynamic fractional amplitude of low-frequency fluctuation in patients with methamphetamine dependence using resting-state functional magnetic resonance imaging
10.3760/cma.j.cn113661-20240110-00022
- VernacularTitle:甲基苯丙胺依赖患者大脑静息态功能磁共振成像动态与静态分数低频振荡振幅研究
- Author:
Jie WANG
1
;
Yadi LI
;
Shuyuan WANG
;
Ping CHENG
;
Mingyu ZHANG
;
Wenhua ZHOU
;
Huifen LIU
;
Wenwen SHEN
;
Gaoyan WANG
;
Haibo DONG
Author Information
1. 宁波大学附属李惠利医院（宁波市医疗中心李惠利医院）放射科，宁波 315100
- Publication Type:Journal Article
- Keywords:
Methamphetamine;
Magnetic resonance imaging;
Fractional amplitude of low frequency fluctuation;
Support vector machine
- From:
Chinese Journal of Psychiatry
2025;58(1):12-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference in brain activity intensity between methamphetamine (MA) dependent patients (MA group) and healthy controls (control group) using fractional amplitude of low-frequency fluctuation (fALFF), and to establish a classification model between these two groups using support vector machine (SVM).Methods:From February 2014 to October 2019, a total of 46 male MA-dependent patients and 46 male healthy controls were recruited from the Affiliated Kangning Hospital of Ningbo University. The study collected resting-state functional magnetic resonance imaging (rs-fMRI) data and analyzed the differences in brain functional activity between the two groups. This analysis was conducted using both static and dynamic fractional amplitude of low-frequency fluctuations (d-fALFF). Additionally, the study examined the correlation between fALFF/d-fALFF values in specific brain regions and the total scores, as well as each factor score, of the Brief Psychiatric Rating Scale (BPRS). Furthermore, the relationship between fALFF/d-fALFF values and the age of first use and total dose of MA in the MA group was investigated. Finally, the fALFF map and d-fALFF map of brain regions with significant differences between groups were used as features for constructing classification.Results:Compared to the healthy control group, those dependent on MA showed significantly increased fALFF mainly in the nucleus accumbens, caudate nucleus, thalamus, and amygdala nucleus( t=-5.21--2.72, all P<0.05). The MA group exhibited decreased fALFF in the superior frontal gyrus, middle frontal gyrus, orbital gyrus, and cingulate gyrus( t=3.59-5.00, all P<0.05). Most of the brain regions with decreased d-fALFF overlapped with those exhibiting decreased fALFF( t=3.33-4.87, all P<0.05). The results of the correlation analysis showed that the fALFF value of the right nucleus accumbens was positively correlated with the age of first use of MA ( r=0.537, P<0.001). There is no significant relationship between the abnormal fALFF and d-fALFF values in the MA group and the total scores and each factor scores of BPRS, as well as the total dose of MA taken (after removing outliers). Based on fALFF and d-fALFF values, the SVM classifier achieved accuracies of 90.33%±6.89% and 71.56%±7.80%, respectively. Conclusions:There are significant abnormalities in the low-frequency fluctuation of the resting brain in patients dependent on MA. These abnormalities reflect the rigidity of prefrontal cortex activity, functional impairment, and dysfunction of the anti-reward system. These factors may be one of the causes for MA dependent behavior and repeated episodes. In addition, the fALFF values may be helpful for distinguishing MA dependent individuals from the control group.
