Research progress on the study of visual system assessment as biomarkers for the diagnosis of schizophrenia
10.3760/cma.j.cn113661-20231220-00252
- VernacularTitle:精神分裂症诊断中视觉相关标志物的研究进展
- Author:
Yuxuan XIONG
1
;
Dan ZHANG
1
;
Lihua XU
1
;
Xu LIU
1
;
Jijun WANG
1
;
Tianhong ZHANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心脑电影像研究室，上海 200030
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Biological markers;
Eye movements;
Fundus oculi
- From:
Chinese Journal of Psychiatry
2024;57(12):859-864
- CountryChina
- Language:Chinese
-
Abstract:
Given the intimate connection between the visual system and the central nervous system, the study of eyes holds paramount importance in the investigation of psychiatric disorders. Some eye movement features, such as restricted visual scanning, declines in responsive search score (RSS), elevated error rates in antisaccades, spatial-temporal anomalies in microsaccades and an integrated eye movement score are considered as potential biomarkers of schizophrenia. Meanwhile, alterations in retinal vascular morphology, thinning of the retinal nerve fiber layer, abnormal electroretinography (ERG), and morphological variations in the cornea and iris also hold indicative significance for the detection of schizophrenia. This review discussed several methods of visual system assessment in clinical practice, aiming to provide insights into visual systems as biomarkers for mental illnesses.
