Differential analysis of circadian rhythm pathway gene polymorphisms in patients with depression and bipolar disorder
10.3760/cma.j.cn113661-20230928-00103
- VernacularTitle:抑郁症与双相障碍患者昼夜节律通路基因多态性的差异分析
- Author:
Lei CHEN
1
;
Zimu CHEN
;
Tian SHEN
;
Tingting TAN
;
Chenjie GAO
;
Suzhen CHEN
;
Bingwei CHEN
;
Yonggui YUAN
;
Zhijun ZHANG
;
Zhi XU
Author Information
1. 东南大学附属中大医院心理精神科，南京 210009
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Bipolar disorder;
Circadian rhythm pathway gene;
Polymorphsim
- From:
Chinese Journal of Psychiatry
2024;57(8):495-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences of the circadian rhythm gene polymorphisms between patients with major depressive disorder and those with bipolar disorder, providing a genetic basis for differential diagnosis.Methods:70 patients who were still diagnosed with major depressive disorder after 5 years and 68 patients who were still diagnosed with bipolar disorder from Zhongda Hospital affiliated to Southeast University from 2012 to 2018 were included in this study. Single nucleotide polymorphisms (SNPs) of circadian rhythm gene were selected for genetic testing. And the differences in genotype frequency, allele frequency, and haplotypes of each SNP between major depressive disorder and bipolar disorder were analyzed using UNPHASED 3.1.7.Results:The analysis of genotype frequency revealed statistically significant differences in genotype frequency of PER1rs2253820, PER1rs2735611, PER3rs12566042, PER3rs17031614, and PER3rs79372391 between the two groups ( OR(95% CI)=2.386(1.173-4.854), 2.357(1.166-4.764), 0.351(0.176-0.703), 0.389(0.196-0.773), 0.389(0.196-0.773) respectively; all P<0.05). Haplotype analysis showed that the T-C-C-T-G haplotype, in CLOCK loci (rs12505266, rs2272073, rs3817444, rs11133389 and rs12505265) was significantly different between major depressive disorder group and bipolar disorder group ( OR(95% CI)=0.108(0.010-1.185), P=0.027). Conclusion:There are significant differences in circadian rhythm gene polymorphisms between patients with major depressive disorder and bipolar disorder. Carrying the PER1rs2253820TT and PER1rs2735611GG genotypes is a risk factors for bipolar disorder.
