Efficacy and safety of dye-free submucosal injection solution for gastric endoscopic submucosal dissection
10.3760/cma.j.cn321463-20250402-00138
- VernacularTitle:不含染色剂的黏膜下注射液在胃内镜黏膜下剥离术中的应用效果及安全性
- Author:
Wan LU
1
;
Yonggang DING
;
Ting ZHANG
;
Lijuan MAO
;
Jing CHEN
;
Yuhong ZHOU
;
Jun XIAO
;
Wenjie LI
;
Yaohui WANG
;
Qide ZHANG
Author Information
1. 南京中医药大学附属医院（江苏省中医院）消化内镜中心，南京 210029
- Publication Type:Journal Article
- Keywords:
Endoscopic submucosal dissection;
Submucosal injection solution;
Efficiency;
Safety
- From:
Chinese Journal of Digestive Endoscopy
2025;42(10):823-827
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the efficacy and safety of dye-free submucosal injection solution for gastric endoscopic submucosal dissection (ESD), a retrospective cohort study was performed on data of inpatients with early gastric cancer and precancerous lesions who underwent ESD at the Digestive Endoscopy Center of Jiangsu Province Hospital of Traditional Chinese Medicine from January to December 2020. Cases were divided into dye-free submucosal injection solution group (the observation group) and dye-containing solution group (the control group). A total of 108 cases met the eligibility criteria for analysis (39 VS 69). Baseline characteristics were comparable between the two groups ( P>0.05). Compared with the control group, the observation group showed similar median procedure time (30.5 min VS 35.0 min), median dissection speed (0.3 cm2/min VS 0.4 cm2/min), mean volume of injection solution used (39.2 mL VS 38.8 mL), en bloc resection rate [100.0% (39/39) VS 98.6% (68/69)], and curative resection rate [97.4% (38/39) VS 97.1% (67/69)] (all P>0.05). Postoperative stay was 3.0±0.8 days in the observation group and 3.2±0.8 days in the control group ( t=-0.908, P=0.378). Delayed bleeding occurred in 3 (7.7%) patients VS 2 (2.9%) patients ( P=0.349), and postoperative infection occurred in 3 (7.7%) patients VS 8 (11.6%) patients ( P=0.743), respectively. In gastric ESD, dye-free submucosal injection solution demonstrates efficacy comparable with dye-containing solution and does not appreciably increase the incidence of intraoperative or postoperative complications.
