Research progress on correlations between intestinal flora and antipsychotic drug-induced metabolic syndrome
10.3760/cma.j.cn113661-20210525-00170
- VernacularTitle:肠道菌群与抗精神病药所致代谢综合征相关研究进展
- Author:
Ningning LI
1
;
Siying XIANG
1
;
Yifeng XU
1
;
Jianhua CHEN
1
Author Information
1. 上海交通大学医学院附属精神卫生中心 上海市精神心理疾病临床医学研究中心，上海200030
- Publication Type:Journal Article
- Keywords:
Antipsychotic agents;
Metabolic syndrome;
Gut flora
- From:
Chinese Journal of Psychiatry
2022;55(1):73-78
- CountryChina
- Language:Chinese
-
Abstract:
Second-generation antipsychotics are widely used in psychiatric disorders such as schizophrenia, however long-term use of second-generation antipsychotics is associated with an increased risk of metabolic syndrome. The etiological mechanisms of metabolic syndrome induced by antipsychotics remain unclear while relationships between intestinal flora and metabolic disorders has attracted increasing attention. Studies have shown that patients with metabolic syndrome induced by antipsychotics have unique characteristics of intestinal flora, and exploratory treatments targeting gut flora lead to preliminary clinical benefits. Intestinal flora may involve in the occurrence and development of metabolic syndrome through regulation of immune, inflammatory, nerve, gene expression and other aspects. In this review, relevant studies investigating the correlations between intestinal flora and metabolic syndrome induced by antipsychotics are reviewed to provide insights for future etiological mechanism research and treatment.
