Research progress on longitudinal changes of brain structure in patients with schizophrenia
10.3760/cma.j.cn113661-20230901-00050
- VernacularTitle:精神分裂症患者脑结构纵向变化的研究进展
- Author:
Qitong JIANG
1
;
Qijing BO
1
;
Lei ZHAO
1
;
Tian LI
1
;
Zhenzhu CHEN
1
;
Yimeng WANG
1
;
Chuanyue WANG
1
Author Information
1. 首都医科大学附属北京安定医院 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室 北京脑重大疾病研究院精神分裂症研究所，北京 100088；首都医科大学人脑保护高精尖创新中心，北京 100069
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Magnetic resonance imaging;
Antipsychotic agents
- From:
Chinese Journal of Psychiatry
2024;57(6):383-389
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is a chronic disabling disease of unknown etiology. Its neuroimaging abnormalities have been confirmed by a large number of studies. However, when these structural abnormalities occur and how they develop over time are unclear. The relationship between structural abnormalities and antipsychotic treatment needs to be further explored. Longitudinal studies on the brain structure of clinical high risk for psychosis, first-episode schizophrenia and chronic schizophrenia, exploring the influence of drug therapy on them, are helpful to construct the trajectories of brain structure changes in the whole course of schizophrenia and dynamically track the brain structure changes, so as to further explore the pathophysiology of schizophrenia. This article reviews the longitudinal research progress of brain structure changes in patients with schizophrenia.
