Research progress on the regulation role of orexin on depressive disorder
10.3760/cma.j.cn113661-20230727-00015
- VernacularTitle:食欲素对抑郁障碍调节作用的研究进展
- Author:
Xiaofeng LI
1
;
Minxia ZHU
1
Author Information
1. 高原低氧环境与生命健康实验室 西藏民族大学医学院，咸阳 712082
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Orexin;
Hypothalamus;
Stress
- From:
Chinese Journal of Psychiatry
2024;57(5):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Depressive disorder is the main cause of suicide death. According to data released by the World Health Organization, approximately 5% of adults globally suffer from depression in 2023, making it the primary threat to mental health. A large number of studies have shown that neurotransmitter imbalance is a common pathogenesis of depressive disorder. As an important neuropeptide neurotransmitter, orexin not only participates in regulating sleep-wake cycles and feeding behaviors related to depressive disorders, but can also directly act on multiple brain regions to bidirectionally regulate depression. This article reviews the regulatory role of orexin in different brain regions on the pathogenesis of depressive disorders, and the changes in orexin secretion levels in acute/chronic stress-induced depressive disorders. This is intended to provide a reference for the basic research on the pathogenesis of depressive disorders and to explore new targets for the clinical diagnosis and treatment of depressive disorder.
