Research advances on aberrant microglial in different brain regions and their impact on the pathogenesis of schizophrenia
10.3760/cma.j.cn113661-20230727-00016
- VernacularTitle:不同脑区小胶质细胞异常影响精神分裂症发病的研究进展
- Author:
Fuyi QIN
1
;
Qing LONG
;
Yilin LIU
;
Yunqiao ZHANG
;
Xu YOU
;
Zeyi GUO
;
Xiang CAO
;
Xinling ZHAO
;
Jia WEN
;
Xinrui LI
;
Yuan FANG
;
Yong ZENG
Author Information
1. 昆明医科大学第二附属医院，昆明650000
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Microglia;
Hippocampus;
Prefrontal lobe;
Temporal lobe;
Brain structure;
Cell signaling pathway
- From:
Chinese Journal of Psychiatry
2024;57(3):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Schizophrenia is a serious mental disorder that is often associated with profound impairment in patients′ daily functioning, and its etiology and pathophysiology are still to be fully elucidated. There is a pathological correlation between inflammation, brain injuries, and the pathogenesis of schizophrenia, with microglia actively participating in these processes. This review provides a comprehensive overview of the impact of microglial cells on neurodevelopment and neuroplasticity, and microglia abnormalities mediating the onset of schizophrenia by contributing to damage in different brain regions.
