Analysis of brain network activations patterns and gender differences in depressed patients under psychosocial stress
10.3760/cma.j.cn113661-20231016-00143
- VernacularTitle:抑郁症患者心理社会应激下脑网络激活特点及性别差异分析
- Author:
Daifeng DONG
1
;
Xiaocui ZHANG
1
;
Chuting LI
1
;
Chang CHENG
1
;
Xiaoqiang SUN
1
;
Ge XIONG
1
;
Shuqiao YAO
1
Author Information
1. 中南大学湘雅二医院医学心理中心 中南大学医学心理研究所 国家精神心理疾病临床医学研究中心，长沙410011
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Adult;
Stress;
Sex;
Brain network
- From:
Chinese Journal of Psychiatry
2024;57(5):282-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the activation patterns of the default mode network (DMN), executive central network (ECN), salience network (SN), and frontoparietal network (FPN) in depressed patients under psychosocial stress processing, and the gender differences.Methods:A prospective study was conducted to collect clinical data, behavior data, and functional magnetic resonance imaging (fMRI) data under psychosocial stress tasks from first-episode, unmedicated depressed patients (depression group,124 cases) who visited the outpatient department of the Second Xiangya Hospital of Central South University from July 2017 to September 2019, including 48 males, aged ( M ( Q1, Q3)) 25 (21, 28) years, and 76 females, aged 26(19, 31) years. At the same period, behavioral data and fMRI data under psychosocial stress tasks were prospectively collected from healthy controls (control group,243 cases) from universities and communities in Changsha, including 106 males, aged 21(19, 21) years, and 137 females, aged 21(20, 21) years. Independent component analysis was used to detect the DMN, ECN, SN, and FPN activation values in each group under psychosocial stress tasks. Repeated measures ANOVA was used to detect the between-group differences in the activation values of the networks of interest. Results:Compared with the healthy control group, the depression group exhibited significantly reduced activation of the SN under stress tasks (activation value: 0.01±0.01vs 0.03±0.01; F=6.50, P=0.011). The brain activation pattern of the FPN showed a significant diagnostic and gender interaction effect ( F=4.30, P=0.039). Simple effect analysis revealed that only the female depression group exhibited significantly reduced negative activation of the FPN under stress tasks compared with the corresponding gender healthy control group (activation value:-0.42±0.06 vs -0.62±0.05; PBonferroni-corrected=0.015, 95%CI=0.038-0.352). Conclusion:Depressed patients exhibit gender-consistent and gender-specific brain network activity patterns during stress processing.
