Research progress on immune inflammatory mechanism of metabolic syndrome comorbidity of depression

VernacularTitle:抑郁症共病代谢综合征免疫炎症机制的研究进展
Author: Yangyu WU ¹ ; Jianzhao ZHANG ¹ ; Xiaodong SONG ¹ ; Shuming ZHONG ¹ ; Yanbin JIA ¹
Author Information

1. 暨南大学附属第一医院精神医学科，广州510630
Publication Type:Journal Article
Keywords: Depressive disorder; Metabolic syndrome; Immune inflammation; Pathological mechanism
From: Chinese Journal of Psychiatry 2024;57(4):245-250
CountryChina
Language:Chinese
Abstract: The prevalence of metabolic syndrome(MetS) in patients with major depressive disorder (MDD) is significantly higher than that in healthy people. Metabolic disorder has been proven to be closely related to the onset of MDD, adverse treatment outcome and disease recurrence. Therefore, revealing the comorbidity mechanism of both is of great significance for treating MDD. Previous studies have focused on the role of abnormal cortisol levels mediated by hypothalamic-pituitary-adrenal axis disorder, but how this pathway is activated and regulated is still unclear. In recent years, with further research development, systemic inflammation induced by an abnormal immune system is considered the deep molecular mechanism of MetS comorbidity of MDD. This review aims to summarize the similar activation of innate immunity, adaptive immunity and immune signaling pathway between MDD and MetS and to provide a strong theoretical basis for follow-up mechanism exploration, drug research and intervention strategy search.