Expression of genes related to mitochondrial function in patients with manic episodes of bipolar disorder
10.3760/cma.j.cn113661-20231014-00139
- VernacularTitle:双相情感障碍躁狂发作患者线粒体功能相关基因表达分析
- Author:
Wenli ZHU
1
;
Shuhui LI
;
Chuanfu SONG
;
Liangshuang YIN
;
Chunling WAN
;
Jie JIANG
Author Information
1. 芜湖市第四人民医院精神科，芜湖241002
- Publication Type:Journal Article
- Keywords:
Bipolar disorder;
Mitochondria;
Gene expression;
Oxidative phosphorylation
- From:
Chinese Journal of Psychiatry
2023;56(6):427-434
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to explore the expression characteristics of mitochondrial function-related genes in patients with manic episodes of bipolar disorder and the correlation between differentially expressed genes and clinical metabolic indicators.Methods:Twenty patients with manic episodes of bipolar disorder (patient group) and 20 healthy controls (control group) were included. Quantitative real-time PCR was used to detect mitochondrial quality control and oxidative phosphorylation-related gene expression in peripheral blood leukocytes, and several metabolic indicators were collected. Mann-Whitney test or independent sample t-test was used for comparison between groups. Spearman correlation test was used to analyze the correlation between gene expression and metabolic indicators. Results:Mitochondria function-related genes, including NRF2, P62, MFN1, MFN2, YME1L, MFF, MTATP8, and AIF, were significantly lower in patients with bipolar disorder than in healthy controls ( P<0.05, U=86, 90, 97, 93, 106, 89, 93, 105, FDR=0.038). The expression level of MTATP8 was negatively correlated with BMI, total cholesterol, and globulin level in the patient group ( r=-0.49, -0.58, -0.46, P=0.028, 0.009, 0.050). The expression level of MFF was significantly negatively correlated with waist circumference in healthy controls ( r=-0.53, P=0.020) and with globulin level in the patient group ( r=-0.48, P=0.040). The expression level of AIF was significantly and positively correlated with high-density lipoprotein cholesterol in healthy controls ( r=0.53, P=0.036). Conclusion:The expression of several genes involved in mitochondrial quality control and oxidative phosphorylation processes was significantly downregulated, and differentially expressed genes were significantly associated with metabolic index, suggesting that mitochondrial dysfunction may be related to the high risk of metabolic disease in patients with manic episodes of bipolar disorder.
