Advances in the antidepressant actions and potential mechanisms of psychedelics

VernacularTitle:致幻剂类药物的抗抑郁作用及其潜在机制研究进展
Author: Denong LIU ¹ ; Zhipeng YU ; Peng XU ; Zhongze LOU ; Liemin RUAN ; Haowei SHEN
Author Information

1. 宁波大学医学院生理与药理学系，宁波　315211
Publication Type:Journal Article
Keywords: Hallucinogen; Depressive disorder; Receptor, serotonin, 5-HT2A
From: Chinese Journal of Psychiatry 2023;56(3):199-204
CountryChina
Language:Chinese
Abstract: Major antidepressants for the treatment of depression have several shortcomings such as delayed therapeutic action, limited remission rate and various adverse effects. Psychedelics are a group of psychoactive substances that can improve perception, mood and cognition. An increasing body of evidence shows that psychedelics positively promote individual social functioning and have a rapid and sustained improvement in moderate or severe depression. Therefore, the antidepressant effects of psychedelics have gained increasing attentions in recent years. This review summarizes the progress of research on the antidepressant effects of some representative psychedelics and their potential mechanisms of antidepressant action, and discusses the risks of clinical application of psychedelics.