The functional characteristics of frontoparietal network information integration and separation in patients with obsessive-compulsive disorder
10.3760/cma.j.cn113661-20220610-00152
- VernacularTitle:强迫症患者额顶叶网络信息整合与分离功能特点
- Author:
Yibo GENG
1
;
Hongxing ZHANG
;
Xiaoyue WANG
;
Yahui LIU
;
Xiaoran WU
;
Xueke WANG
;
Qiaohua CHANG
;
Qingjiang ZHAO
;
Jiajia ZHANG
;
Entu ZHANG
;
Lunpu AI
;
Haisan ZHANG
Author Information
1. 新乡医学院第二附属医院磁共振科 河南省精神病医院 新乡市多模态脑影像重点实验室 新乡市精神影像工程技术研究中心，新乡 453002
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Magnetic resonance imaging;
Functional brain network;
Functional integration and separation
- From:
Chinese Journal of Psychiatry
2023;56(1):17-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the functional changes of brain network node information integration and separation in patients with obsessive-compulsive disorder (OCD) and its correlation with clinical symptoms.Methods:Fifty-six patients with obsessive-compulsive disorder (OCD group) and fifty-six healthy controls (control group) matched in gender, age and years of education were enrolled. All participants accepted resting-state functional magnetic resonance imaging scans of the whole brain. Yale-Brown Obsessive Compulsive Scale(Y-BOCS) was used to assess patients′ clinical symptoms. Based on graph theory and independent-sample t-test, the differences in functional network topological properties of nodes between the two groups were analyzed. Partial correlation analysis was used to discuss the relationship between the values of these properties and clinical symptoms. Results:Compared with the control group, the OCD group showed decreased global efficiency and increased shortest path length of the left superior temporal gyrus rostral area and right posterior central gyrus trunk region(both P<0.001, FDR corrected); decreased local efficiency( P=0.002, uncorrected) and clustering coefficient( P<0.001, FDR corrected) of the left inferior frontal gyrus dorsal region. Further analysis showed that the score of the global efficiency of the left superior temporal gyrus rostral area was positively correlated with the score of obsessive thoughts sub-scale ( r=0.390, P=0.005). The score of the shortest path length of the left superior temporal gyrus rostral area was negatively correlated with the obsessive thoughts sub-scale ( r=-0.359, P=0.010) in the OCD group. Conclusion:OCD patients have abnormal information integration and separation functions in the frontoparietal network(inferior frontal gyrus, posterior central gyrus) and abnormal information integration functions in the superior temporal gyrus rostral area. Higher global efficiency and shorter the shortest path length of the superior temporal gyrus rostral area suggest more obsessive thoughts in OCD patients.
