Maternal immune activation leads to metabolic disorders and systemic inflammatory responses in rat offspring
10.3760/cma.j.cn113661-20211019-00311
- VernacularTitle:孕期母体免疫激活导致子代大鼠代谢紊乱及系统性炎症反应
- Author:
Xi SU
1
;
Meng SONG
1
;
Minglong SHAO
1
;
Yongfeng YANG
1
;
Luxian LYU
1
;
Wenqiang LI
1
Author Information
1. 河南省精神病医院 新乡医学院第二附属医院重点实验室 河南省生物精神病学重点实验室，新乡453002
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Metabolic syndrome X;
Inflammation;
Maternal immune activation
- From:
Chinese Journal of Psychiatry
2022;55(4):281-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study evaluated the metabolic phenotype in offspring of maternal immune activation(MIA) rats, to determine whether it applies to the study of the mechanism of metabolic syndrome associated with schizophrenia, and to analyze its possible pathogenesis.Methods:Polyinosinic-polycytidylic acid (Poly I:C) or saline was injected via tail vein at 9.5 days of pregnancy, and the offspring were defined as MIA group and control group. Behavior, blood routine, blood glucose, blood lipid and liver function were detected. Besides, inflammatory cytokine levels were analyzed by quantitative PCR. The independent -sample t-test was used for the comparison between groups. Results:The results showed that the rats of the MIA group had an increased anxiety level, memory impairment, and sensory gating dysfunction in early adulthood. However, the rats of the MIA group already showed the risk of metabolic disorders in their adolescence, including the increased proportion of monocytes ( t=2.50, df=14, P=0.028), elevated LDL-C level ( t=3.34, df=14, P=0.005), and increased atherosclerosis index ( t=2.23, df=14, P=0.043). The rats of the MIA group showed abnormal liver morphology and decreased globulin ( t=3.61, df=14, P=0.003) and total protein levels ( t=3.40, df=14, P=0.004), suggesting possible impaired liver function. In addition, the rats of the MIA group showed systemic inflammation of the brain and liver. Conclusion:These results demonstrate that behavioral disorders and metabolic disorders coexist in the rats of the MIA group, and metabolic disorders appear earlier than significant behavioral abnormalities, suggesting the possible value of this model in the study of schizophrenia complicated by metabolic syndrome. In addition, systemic inflammation of the brain and liver may be a possible mechanism for behavioral disorders and metabolic disorders in the offspring of MIA.
