Role of exosomes in the pathogenesis of common mental disorders: a review
10.3760/cma.j.cn113661-20210708-00220
- VernacularTitle:外泌体在常见精神障碍发病中的研究进展
- Author:
Xiaosi HUANG
1
;
Xiaodan LU
1
;
Yiliang ZHANG
1
;
Hui ZHAO
1
;
Yanbin JIA
1
Author Information
1. 暨南大学附属第一医院精神医学科，广州 510630
- Publication Type:Journal Article
- Keywords:
Mental disorders;
Exosomes;
Depressive disorder;
Bipolar disorder;
Schizophrenia;
Pathogenesis
- From:
Chinese Journal of Psychiatry
2022;55(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Recent research has presented emerging evidence of the involvement of intercellular communication, neuroplasticity, neuroinflammation, epigenetics and neural regeneration in the pathogenesis of mental disorders. Exosomes are nano-sized membrane vesicles secreted by different types of cells and contain a diverse suite of biomolecules including proteins, lipids, nucleic acids, especially micro-ribonucleic acid, and so on. Exosomes have been shown to play crucial roles in cell-to-cell communication and other pathophysiological processes because of their unique ability to carry biofunctional molecules. It may prove that exosomes are involved in the pathogenesis of psychiatric diseases. Moreover, recent findings have revealed that exosomes can be used as potential drug/gene carriers, therapeutic agents, and diagnostic tools. The purpose of this narrative literature review is to discuss the possible role of exosomes in mental disorders, providing strategies for further studies of exosomes as precision medicines and possible diagnostic biomarkers.
