Risk factors for adverse reactions during intestinal preparation for colonoscopy
10.3760/cma.j.cn321463-20240522-00117
- VernacularTitle:肠道准备过程中不良反应的相关危险因素分析
- Author:
Qiaoyu SU
1
;
Yingjie ZHANG
;
Zeyu WANG
;
Xiaoyu KANG
;
Yanglin PAN
Author Information
1. 西安医学院，西安 710068
- Publication Type:Journal Article
- Keywords:
Colonoscopy;
Bowel preparation;
Adverse events;
Risk factors
- From:
Chinese Journal of Digestive Endoscopy
2025;42(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the adverse reactions and its risk factors during bowel preparation prior to colonoscopy.Methods:The clinical data of 1 727 patients who underwent colonoscopy at the First Affiliated Hospital of Air Military Medical University from September 2019 to March 2021 were analyzed retrospectively. The primary endpoint was the incidence of adverse reactions during bowel preparation. The risk factors of adverse reactions were identified by logistic regressions.Results:The incidence of overall adverse reactions was 54.9% (948/1 727). The incidences of nausea, vomiting, and abdominal discomfort were 38.6% (666/1 727) , 10.2% (177/1 727), 25.9% (447/1 727), respectively. Multivariate logistic regression analysis showed that being female ( OR=1.77, 95% CI: 1.45-2.17, P<0.001), history of abdominal surgery ( OR=1.38, 95% CI:1.08-1.75, P=0.009), inflammatory bowel disease ( OR=1.77, 95% CI: 1.08-2.91, P=0.024) were independent risk factors for adverse reactions during bowel preparation. Female gender ( OR=2.37, 95% CI: 1.66-3.38, P=0.001) and history of abdominal or pelvic surgery ( OR=1.45, 95% CI: 1.02-2.06, P=0.038) were independent risk factors for vomiting, while body mass index ≥25 kg/㎡( OR=0.48, 95% CI: 0.28-0.80, P=0.005) and age≥60 years ( OR=0.58, 95% CI: 0.38-0.89, P=0.013) were protective factors for vomiting during bowel preparation. Conclusion:A significant portion of patients experience adverse reactions during bowel preparation for colonoscopy. The risk factors of adverse reactions include female, history of abdominal surgery and inflammatory bowel disease. Female and a history of abdominal surgery are independent risk factors for vomiting, while obesity and old age are protective factors for vomiting during bowel preparation.
