Analysis of clinical features of esophageal neuroendocrine neoplasms
10.3760/cma.j.cn321463-20240807-00361
- VernacularTitle:食管神经内分泌肿瘤的临床特征分析
- Author:
Ping HU
1
;
Na HE
1
;
Lijun YAN
1
;
Xiaoya LI
1
;
Jian'an BAI
1
;
Guoqin ZHU
1
;
Ye TIAN
1
;
Qiyun TANG
1
Author Information
1. 南京医科大学第一附属医院老年消化科，南京 210029
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neuroendocrine tumors;
Carcinoma, neuroendocrine;
Prognosis;
Endoscopic submucosal dissection;
Chemotherapy
- From:
Chinese Journal of Digestive Endoscopy
2024;41(12):1002-1007
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the clinical features of esophageal neuroendocrine neoplasms (eNENs) and the role of endoscopic submucosal dissection (ESD) in the management of eNENs, clinicopathologic features and outcomes of 34 patients with eNENs (30 patients diagnosed by histopathology in the First Affiliated Hospital with Nanjing Medical University from January 2010 to December 2022 and 4 patients who underwent ESD reported in PubMed from January 2014 to December 2023) were retrospectively analyzed. Survival analysis was performed to identify prognostic factors of eNENs. The vulnerable patients of eNENs were elderly males (79.41%, 27/34) and the age of onset was 65.41±8.78 years. The lesions mostly occurred in the middle (41.18%, 14/34) and lower (41.18%, 14/34) esophagus. Dysphagia was the most common clinical manifestation, accounting for 58.82% (20/34). The median overall survival time was 36.31 months and the 1, 3, 5-year overall survival rate was 82.35%, 53.45% and 27.94% respectively. In the univariate analysis, the prognosis of eNENs varied in different location, size, stage and treatment strategies ( P<0.05). The primary tumor resection was an independent prognostic factor for the survival of eNENs in multivariate analysis ( P=0.041, HR=0.166, 95% CI: 0.030-0.927). The median survival time of the patients with primary tumor resection was significantly longer than that without resection (42.98 months VS 17.90 months, P=0.005). Whereas, there was no significant difference in median survival time between the patients who underwent surgical operation and those who underwent ESD (43.93 months VS 39.50 months, P=0.835). eNENs has no specific clinical manifestations. Resection of the primary tumor is a protective factor for the prognosis of eNENs. ESD has a comparable result to surgery and can be considered as a treatment modality for paticular patients.
