An experimental study of a novel suture instrument for endoscopic closure of full thickness defects of the gastric wall
10.3760/cma.j.cn321463-20240509-00276
- VernacularTitle:新型缝合器械胃镜下修补胃壁全层缺损的实验研究
- Author:
Chunbo YU
1
;
Mingxian CHEN
;
Meihua CHEN
;
Liang HUANG
;
Yijing LIU
;
Shufang TAO
;
Yanhong HE
;
Weizhong YAN
;
Dong LI
Author Information
1. 上海市嘉定区安亭医院普外科，上海 201805
- Publication Type:Journal Article
- Keywords:
Surgical staplers;
Suture techniques;
Swine;
Endoscopic hand-suturing
- From:
Chinese Journal of Digestive Endoscopy
2025;42(1):47-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility, safety, and effectiveness of a novel suture instrument for closure of full thickness defects of the gastric wall under gastroscopy.Methods:Ten pigs were used as experimental animals. Perforation model (30 mm in long diameter) was created in the stomach of each pig. The perforations were then closed by the novel suture instrument under gastroscopy. The completion time and efficacy of each perforation repair were recorded. The pigs were euthanized 14 days after the procedure. The healing condition was observed under gastroscopy. A postmortem examination was performed to observe the abdominal infection and healing condition of perforation. Ascites sample was taken for bacterial culture.The stomach biopsy were taken for histopathologic examination.Results:All gastric perforation models in the 10 pigs were established successfully. Endoscopic closure for the stomach perforation was technically successful in all 10 pigs. The procedure time was 34.10±10.32 minutes. All animals survived. Gastroscopy and necropsy showed that the perforation healed well with local adhesion. One pig developed abdominal infection. Ascites culture were negative in 9 cases, 1 bacterial infection was caused by Arcanobacterium pyogenes and Escherichiacoli. The pathology results showed that the muscular layer of the gastric wall defect in the entire group was well repaired. Conclusion:The novel suture instrument is safe and effective in repairing full-thickness gastric wall defects under ordinary single clamp gastroscopy, providing an experimental basis for further clinical research.
