Computerized cognitive remediation therapy improved cognition in patients with mild cognitive impairment: a randomized controlled study
10.3760/cma.j.cn113661-20210108-00018
- VernacularTitle:计算机认知矫正治疗改善轻度认知功能障碍的随机对照研究
- Author:
Lan WANG
1
;
Lulu YU
1
;
Mei SONG
1
;
Qifeng ZHU
1
;
Yuanyuan GAO
1
;
Xiaochuan ZHAO
1
;
Keyan HAN
1
;
Cuixia AN
1
;
Xueyi WANG
1
Author Information
1. 河北医科大学第一医院精神卫生中心 河北省精神卫生研究所 河北省脑老化与认知神经科学实验室 河北省脑科学与精神心理疾病重点实验室，石家庄 050031
- Publication Type:Journal Article
- Keywords:
Cognitive therapy;
Computers;
Mild cognitive impairment
- From:
Chinese Journal of Psychiatry
2021;54(4):259-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of computerized cognitive remediation therapy(CCRT) in the patients with mild cognitive impairment (MCI).Methods:A randomized, single-blinded clinical study was carried out from the April to June in 2019. 46 patients who met MCI criteria were randomly allocated into a CCRT group ( n=24) and a control group ( n=22). In CCRT group, the CCRT was conducted five times a week (30 minutes each time) for a total of 8 weeks (40 times), while a natural observation was performed in the control group. All the subjects were assessed by the Mini-Mental State Examination(MMSE) and the Montreal Cognitive Assessment(MoCA) before and after the treatment. The Wilcoxon test in the paired rank-sum test of two related samples was used to evaluate the effect of CCRT on MCI before and after the intervention, and the Mann-Whitney U test in the rank-sum test of two independent samples was used to compare the differences in MMSE and MoCA scores between the two groups. Results:Before treatment, there were no statistically significant differences in MMSE, MoCA total scores and each factor between the CCRT group and the control group ( P>0.05). A total of 21 patients in CCRT group completed CCRT treatment. After 8 weeks of treatment, the difference between two groups in the total score of MMSE ( Z=-2.83), attention and calculation( Z=-2.58), time orientation( Z=-2.00) and visual spatial function ( Z=-2.45) scores were higher than those before the treatment ( P<0.05); the difference between two groups in MoCA total score ( Z=-3.40), visual space and executive function( Z=-3.41), attention ( Z=-3.09) were higher than those before the treatment ( P<0.05). Conclusion:CCRT may improve the cognitive function of MCI patients, especially the attention and visuospatial functions.
