Correlation between allostatic load and clinical characteristics of first-episode schizophrenia and its influence upon the onset
10.3760/cma.j.cn113661-20201217-00509
- VernacularTitle:非稳态负荷与首次发病精神分裂症患者临床症状的关系及对发病的影响
- Author:
Yanfang ZHOU
1
;
Ping ZHANG
;
Mengzhuang GOU
;
Jinghui TONG
;
Junchao HUANG
;
Ting XIE
;
Ting YU
;
Shuping TAN
;
Zhiren WANG
;
Baopeng TIAN
;
Fude YANG
;
Yunlong TAN
Author Information
1. 北京大学回龙观临床医学院科技处 北京回龙观医院 100096
- Publication Type:Journal Article
- Keywords:
Stress;
Schizophrenia;
Allostatic load
- From:
Chinese Journal of Psychiatry
2021;54(3):184-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the possible correlation between allostatic load (AL) and clinical symptoms in patients with first-episode schizophrenia (FES) and AL influence upon the onset.Methods:Patients with FES (schizophrenia group, n=93) who received treatment at Beijing Huilongguan Hospital from October 2017 to July 2019 and the healthy controls (control group, n=111) recruited during the same period were enrolled in the research. Systolic blood pressure, diastolic blood pressure, resting heart rate, body mass index, waist-hip ratio, high-density lipoprotein cholesterol, total cholesterol, glycosylated hemoglobin, high-sensitivity C-reactive protein, 12-hour urine adrenaline, 12-hour urine norepinephrine, 12-hour urine cortisol, and serum dehydroepiandrosterone of all subjects were collected to calculate the AL index. The positive and negative symptom scale (PANSS) was used to assess the psychopathological symptoms of patients. Covariance analysis was used to compare the differences of AL index and the thirteen biological components between FES patients and controls. Pearson correlation analysis was used to explore the correlation between AL index and clinical symptoms, and the Logistic regression analysis was used to explore the risk factors of schizophrenia. Results:AL index among schizophrenic patients was higher than the controls (5.87±1.90 vs. 3.50±2.21, F=65.97, P<0.001). AL index was possitively correlated with PANSS positive symptoms ( r=0.25, P=0.019) and was a risk factor of schizophrenia ( OR=1.76, 95% CI: 1.47-2.11, P<0.01). Conclusions:The AL is possitively correlated with positive symptoms in the FES, and the higher AL may be one of important inducements to the schizophrenia onset.
