Potential risk factors of comorbidity of major depressive disorder and generalized anxiety disorder-results of a multicenter cross-sectional study
10.3760/cma.j.cn113661-20200401-00157
- VernacularTitle:共病广泛性焦虑障碍的抑郁症患者潜在风险因素的多中心横断面调查
- Author:
Jingyu LIN
1
;
Yunai SU
;
Xiaozhen LYU
;
Qi LIU
;
Gang WANG
;
Jing WEI
;
Gang ZHU
;
Qiaoling CHEN
;
Hongjun TIAN
;
Kerang ZHANG
;
Xueyi WANG
;
Nan ZHANG
;
Ying WANG
;
Xin YU
;
Tianmei SI
Author Information
1. 北京大学第六医院 北京大学精神卫生研究所 卫生部精神卫生重点实验室（北京大学） 国家精神心理疾病临床医学研究中心（北京大学第六医院） 100191
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Anxiety;
Stress, psychological;
Neuroticism;
Cross-sectional studies
- From:
Chinese Journal of Psychiatry
2020;53(4):287-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to examine the prevalence of comorbid generalized anxiety disorder (GAD) among adult patients with major depressive disorder (MDD) in China and explore its potential risk factors.Methods:This is a multicenter, cross-sectional study, involving 1 086 patients in 9 clinical settings. The diagnosis of MDD and GAD were confirmed by the MINI. Life events were evaluated by the Life Events Scale (LES), and early life stress was assessed by the Childhood Trauma Questionnaire (CTQ). The severity of depression, social support, coping style and personality traits were assessed by Hamilton Depression Rating Scale-17 item (HAMD 17), Simplified Coping Style Questionnaire (SCSQ), and Eysenck Personality Questionnaire, short scale for China (EPQ-RSC), respectively. Pearson correlation analysis, univariate regression analysis and Logistic regression analysis were used to explore the association of clinical characteristics, life stress, social factors and comorbidity of MDD and GAD. Results:Among 1 086 MDD patients, 276 of them (25.4%) were diagnosed with comorbid GAD. Patients with comorbid GAD were more likely to report adulthood adversity then those without (60.2% （165/276） vs. 39.9%（321/810）, χ2=33.993， P<0.01). However, there was no difference in social support and coping styles between the two groups. Furthermore, patients with comorbid GAD had higher levels of neuroticism, and lower levels of extraversion. After controlling for confounders, logistic regression results showed that adulthood adversity ( OR=1.720, 95% CI 1.262-2.343, P<0.01) and higher neuroticism levels (O R=1.211, 95% CI 1.141-1.286, P<0.01) were significantly associated with comorbid GAD in patients with MDD. Conclusion:Adulthood adversity and high levels of neuroticism were potential risk factors of comorbidity of MDD and GAD. This finding provides empirical evidence for developing targeted interventions for this subgroup population with MDD.
