Recent advance in atypical antipsychotics induced QTc interval prolongation
10.3760/cma.j.cn113661-20200322-00133
- VernacularTitle:第2代抗精神病药引起QTc间期延长的研究进展
- Author:
Luyao HE
1
;
Wenjuan YU
1
;
Jingjing HUANG
1
;
Huafang LI
1
Author Information
1. 上海交通大学医学院附属精神卫生中心 上海市精神心理疾病临床医学研究中心 上海市重性精神病重点实验室 200030
- Publication Type:Journal Article
- Keywords:
Antipsychotic agents;
QTc interval prolongation
- From:
Chinese Journal of Psychiatry
2021;54(1):50-56
- CountryChina
- Language:Chinese
-
Abstract:
Antipsychotics are the main treatments for schizophrenia, and their adverse effects are of great significance for the selection and optimization of clinical treatment. In terms of drug-induced cardiotoxicity, the QTc interval is usually used as an important evaluation indicator. QTc interval prolongation may cause torsades de pointes and sudden cardiac death. Although atypical antipsychotics have significantly improved safety compared to typical antipsychotics, great attention are still needed regarding drug-related cardiotoxicity. This article summarizes and discusses the relationship and its relevant influencing factors between atypical antipsychotics and QTc interval abnormalities.
