Association between functional network connectivity and suicidal behavior in young patients with depression disorder
10.3760/cma.j.cn113661-20200428-00201
- VernacularTitle:青年抑郁症患者脑功能网络连接与自杀未遂行为的相关性研究
- Author:
Jun CAO
1
;
Xiaorong CHEN
;
Li KUANG
;
Jianmei CHEN
;
Ming AI
;
Yao GAN
;
Wo WANG
;
Zhen LYU
;
Jinglan HE
Author Information
1. 重庆医科大学附属第一医院精神科 400016
- Publication Type:Journal Article
- Keywords:
Depressive disorder;
Suicide，attempted;
Magnetic resonance imaging;
neural networks （computer）
- From:
Chinese Journal of Psychiatry
2020;53(4):300-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the functional connectivity of resting-state networks in young depressed patients with suicide attempts and its association with suicide attempt as well as to better understand the underlying neural mechanism of suicide.Methods:Hamilton Depression Scale-17 items （HAMD 17），Beck Depression Inventory （BDI）, Suicide Attitude Questionnaire （SAQ）, Barratt Impulsiveness Scale （BIS）, Beck Hopelessness Scale （BHS） and Scale for Suicide Ideation （SSI）were used to assess the severity of depressive symptoms and suicidal characteristics in 35 young depressed patients with suicide attempts (SU group), 18 patients with non-suicide attempt （NSU group） and 47 gender, age, and education matched healthy controls (HC group). The alterations of intra-and internetwork connectivity among SU, NSU and HC group were analyzed with functional magnetic resonance imaging and independent component analysis（ICA）. Pearson correlation was adopted to analyze the association between functional network connectivity and clinical psychological scales .Results:(1)There were significant differences in functional network connectivity within the default mode network （DMN），salience network (SN) and bilateral frontal-parietal network （FPN） among three groups. Compared with NSU group, SU showed significantly decreased internetwork connectivity between anterior default mode network （aDMN）, salience network （SN）（ t=-2.63, P=0.036）, and right frontal-parietal network （rFPN）( t=-3.42, P=0.048). However, enhanced internetwork connectivity between the SN and the right fronto-parietal network (rFPN) was found in SU group （ t=3.07, P=0.038）. In addition，decreased aDMN-rFPN connectivity was negatively correlated with BHS scores ( r=-0.353； P=0.037), and the differences in SN-rFPN and aDMN-pDMN connectivity were negatively associated with the HAMD score in the SU group ( r=-0.369, P=0.029； r=-0.372, P=0.028). Conclusions:These findings suggest that SU experience reorganization at the level of large-scale brain networks. Suicide attempt is correlated with abnormal functional network connectivity within and among these RSNs.
