Brain connectivity abnormity analysis in autism spectrum disorder based on magnetic resonance imaging
10.3760/cma.j.cn113661-20190726-00248
- VernacularTitle:基于磁共振成像技术的孤独症患者脑连接异常的研究进展
- Author:
Mengwan LIU
1
;
Hongbing LU
;
Huaning WANG
;
Kaizhong ZHENG
;
Jiaming LI
;
Baoyu YAN
;
Baojuan LI
;
Jian LIU
Author Information
1. 空军军医大学军事生物医学工程学系军事医学信息技术教研室，西安 710032
- Publication Type:Journal Article
- Keywords:
Autistic disorder;
Magnetic resonance imaging;
Brain connectivity
- From:
Chinese Journal of Psychiatry
2020;53(4):351-355
- CountryChina
- Language:Chinese
-
Abstract:
MRI technology has been widely used in brain connectivity analysis to explore the neurobiological mechanism of ASD. Analysis of brain structural connectivity found atypical growth and development in patients with ASD, excessive growth in infancy, and excessive decline in functions from adolescence to middle age. Functional connectivity analysis suggests that default mode network (DMN) may be related to theory of mind (ToM) and self-referential processing, abnormal salience network (SN) connections can lead to social communication disorders, and abnormal reward network (RN) may be related to repetitive and restricted behaviors. Effective connectivity analysis found that information transmission between brain regions was abnormal in ASD patients, which was associated with social dysfunction. This article introduces the latest development of MRI research, and discusses the differences between ASD patients and normal human brain connections, so as to provide theoretical reference for further investigations of the neural activity mechanism of ASD patients.
