Diabetic retinopathy mechanomedicine: a paradigm shift in disease understanding and management
10.3760/cma.j.cn511434-20250414-00170
- VernacularTitle:糖尿病视网膜病变力医学的研究进展
- Author:
Bingqian WEI
1
;
Guorui DOU
;
Feng XU
;
Xin WANG
Author Information
1. 空军军医大学西京医院眼科 全军眼科研究所, 西安 710032
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Retina biomechanics;
Retina mechanobiology;
Retina mechanodiagnostics;
Retina mechanotherapy;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(10):806-811
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a common complication of diabetes that can lead to visual impairment or even blindness. Current treatments mainly rely on invasive methods, which carry the risk of complications, making early intervention crucial. In recent years, research has revealed that the mechanical microenvironment of the retina plays a key role in the development and progression of DR, involving cell migration, functional disorders, and changes in the extracellular matrix. Mechanobiological mechanisms, such as mechanical signal transduction and the Hippo/Yes-associated protein pathway, are gradually being uncovered. Mechanical diagnostic and therapeutic strategies, including optical coherence elastography, tissue engineering, and intelligent diagnostic systems, offer new directions for DR management. In the future, further integration of biomechanics and mechanobiology research is needed to build multi-scale mechanical models and explore the synergistic regulation mechanisms between mechanical and biochemical factors, aiming to achieve precise and personalized diagnosis and treatment of DR and ultimately improve patients' visual outcomes.
