Research progress on the neuroprotective effect of stem cells in age-related macular degeneration
10.3760/cma.j.cn511434-20240925-00358
- VernacularTitle:干细胞对年龄相关性黄斑变性的神经保护作用研究进展
- Author:
Jiansheng FANG
1
;
Yuxiang DU
Author Information
1. 济宁医学院临床医学院, 济宁 272067
- Publication Type:Journal Article
- Keywords:
Age-related macular degeneration;
Stem cell;
Therapy;
Neuroprotection;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2025;41(2):156-162
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is an age-related neurodegenerative eye disease characterized by degeneration and progressive death of retinal pigment epithelium (RPE) and photoreceptor cells. In recent years, as a new treatment for AMD, stem cell therapy has attracted wide attention in the field of AMD, and has become a current research hotspot. Although stem cell therapy carries risks such as increased incidence of cancer and immune rejection, it significantly promotes damaged photoreceptor cells and retinal cells by differentiating into RPE cells and other retinal cell types, as well as secreting neurotrophic factors and extracellular vesicles. In particular, the development of embryonic stem cell-derived RPE cells, its cryopreservation technology and the advancement of plasmid, adeno-associated virus, Sendai virus and other delivery technologies have laid a solid foundation for stem cell therapy of AMD. As a new method to prevent retinal damage and photoreceptor degeneration, stem cell neuroprotective therapy has shown great potential, and with the continuous maturity and improvement of these technologies, stem cell therapy is expected to provide new ideas for the prevention and treatment of AMD in the future.
