Analysis of factors affecting fibrosis reversal in patients with metabolic associated steatohepatitis based on magnetic resonance elastography
10.3760/cma.j.cn501113-20250830-00354
- VernacularTitle:代谢相关脂肪性肝炎患者基于磁共振弹性成像的纤维化逆转影响因素分析
- Author:
Ziyi ZHANG
1
;
Chenglin SUN
;
Hao REN
;
Dawei YANG
;
Xinyu ZHAO
;
Mengyang ZHANG
;
Xiao HAN
;
Jingjie ZHAO
;
Qianyi WANG
;
Yameng SUN
;
Xinyan ZHAO
;
Jidong JIA
;
Zhenghan YANG
;
Xiaofei TONG
;
Hong YOU
Author Information
1. 首都医科大学附属北京友谊医院肝病中心 消化健康全国重点实验室 国家消化系统疾病临床医学研究中心，北京 100050
- Publication Type:Journal Article
- Keywords:
Metabolic associated fatty liver disease;
Liver fibrosis;
Magnetic resonance elastography;
Magnetic resonance imaging proton density fat fraction
- From:
Chinese Journal of Hepatology
2025;33(10):1001-1008
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To dynamically assess liver fibrosis using magnetic resonance elastography (MRE) and explore factors associated with fibrosis reversal in patients with metabolic dysfunction-associated steatohepatitis (MASH).Methods:This study included data from patients diagnosed with MASH by liver biopsy who underwent at least two MRE examinations. Patients were divided into a fibrosis reversal group and a non-reversal group according to whether MRE values decreased by 20% during follow-up. Differences in clinical data between the groups were compared using analysis of variance, the Kruskal-Wallis test, and the chi-square test. Univariate and multivariate logistic regression analyses were used to explore independent risk factors for fibrosis reversal in MASH.Results:A total of 46 cases were included in this study (mean age 50.1±12.3 years, BMI 26.1±3.1 kg/m2). Among them, the reversal group accounted for 26.1%. The rate of decrease in MRI proton density fat fraction (PDFF) was significantly higher in the reversal group (-50.0% vs. -8.1%, P=0.001) than in the non-reversal group between the two MRE examinations. The reversal group showed a more significant change rate of decreases in fasting insulin (-37.3% vs. -3.6%, P=0.011), insulin resistance index (-38.6% vs. -6.5%, P=0.044), and ALP (-24.9% vs. 0, P=0.004). Multivariate logistic regression analysis indicated that the rate of change in MRI PDFF was an independent predictor of fibrosis reversal ( OR=0.96, 95% CI: 0.92-1.00, P=0.046). Conclusion:A decrease in MRI proton density fat fraction levels is independently associated with liver fibrosis reversal in MASH, suggesting that intervention targeting liver fat content may be an effective treatment strategy.
