Research progress on the diagnostic performance and predictive accuracy of different prognostic scores as non-invasive liver fibrosis models for primary biliary cholangitis
10.3760/cma.j.cn501113-20240716-00328
- VernacularTitle:不同预后评分作为原发性胆汁性胆管炎无创肝纤维化模型诊断能力和预测效能的研究进展
- Author:
Juan FENG
1
;
Yuetian LI
1
;
Jiamin XU
1
;
Jingyi ZHANG
1
;
Simiao LI
1
;
Yingmei TANG
1
Author Information
1. 昆明医科大学第二附属医院消化内科，昆明 650000
- Publication Type:Journal Article
- Keywords:
Primary biliary cholangitis;
Prognostic scores;
Liver fibrosis;
Diagnosis;
Transplant-free survival
- From:
Chinese Journal of Hepatology
2025;33(6):607-612
- CountryChina
- Language:Chinese
-
Abstract:
The grade of histological severity is a determining factor to evaluate the prognosis and survival rate in primary biliary cholangitis (PBC). However, liver biopsy is limited by sampling error, invasiveness, high cost, and poor compliance. Therefore, in order to overcome the limitations of liver biopsy, some non-invasive evaluation methods have been studied and applied to evaluate the progression of liver fibrosis in PBC. The prognostic score can be calculated using routine laboratory test results obtained at the time of diagnosis, which are characterized by their simplicity, affordability, ease of acquisition, and superior reproducibility. Recent studies have reported that the prognostic score can be employed as a non-invasive liver fibrosis model to diagnose the liver fibrosis stage in PBC and predict the transplant-free survival rate, in addition to being used to evaluate the patient prognosis and transplant-free survival (TFS). This paper reviews, summarizes, and explores the research progress of different prognostic scores as non-invasive liver fibrosis models via their diagnostic performance and predictive accuracy for PBC.
