Biological characteristics of liver zonation and its role in disease and aging
10.3760/cma.j.cn501113-20241010-00532
- VernacularTitle:肝脏分区的生物学特征及其在疾病和衰老中的角色
- Author:
Peiyuan GU
1
;
Jingxin XIN
;
Keling YIN
;
Changxu ZHOU
;
Ran ZHANG
;
Shanshan SHAO
Author Information
1. 内分泌糖脂代谢与脑老化教育部重点实验室 山东第一医科大学附属省立医院内分泌代谢病科，济南 250021
- Publication Type:Journal Article
- Keywords:
Liver injury;
Hepatocellular carcinoma;
Aging;
Liver metabolic zonation;
Metabolic dysfunction-associated steatotic liver disease;
Monogenic liver disease
- From:
Chinese Journal of Hepatology
2025;33(6):601-606
- CountryChina
- Language:Chinese
-
Abstract:
The liver is the largest visceral organ in the human body, responsible for multiple important functions such as metabolism, detoxification, nutrient storage, and immune regulation. Hepatocytes located along the portal-central vein axis have heterogeneity in gene expression and function, which led to the concept of liver zonation. Cells in different regions play different roles in metabolic processes, and the coordination and cooperation between these cells are crucial for maintaining normal liver function. In recent years, the advancements in single-cell genomics and spatial transcriptomics technologies have significantly improved our understanding of liver zonation. This article summarizes the important role of metabolic zonation in maintaining liver function and its relationship with disease and aging, providing a theoretical basis for further research and therapeutic strategies.
