Current status and challenges of platelet-rich plasma-derived extracellular vesicles in treatment of chronic wounds
10.3760/cma.j.cn114657-20250117-00022
- VernacularTitle:富血小板血浆来源细胞外囊泡治疗慢性创面的研究现状及面临的挑战
- Author:
Shan HUA
1
;
Hongyi ZHANG
;
Jiawei GU
;
Yuxin QIAN
;
Rong GUO
;
Yingshen SHI
;
Yilong WANG
;
Hua JIANG
Author Information
1. 同济大学附属东方医院整形外科，上海 200120
- Publication Type:Journal Article
- Keywords:
Platelet-rich plasma;
Extracellular vesicles;
Chronic wounds;
Molecular mechanisms
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(4):337-342
- CountryChina
- Language:Chinese
-
Abstract:
Chronic wounds, defined as persistent failure to heal due to specific etiological factors, remain a major clinical challenge. Current standard interventions such as negative pressure wound therapy are limited by complications like hypergranulation and poor patient compliance, while emerging stem cell-based therapies carry potential tumorigenic risks. Consequently, identifying strategies to safely and effectively accelerate wound healing continues to be a critical focus in contemporary clinical research. Platelet-rich plasma derived extracellular vesicles (PRP-EVs) are extracellular vesicles released by platelets after activation. They have the characteristics of autologous origin, higher safety, and more mild and convenient clinical application. Studies have shown that PRP-EVs are rich in bioactive molecules such as lipids, proteins and RNA, which have outstanding performance in regulating wound inflammation, promoting angiogenesis, enhancing cell migration and proliferation, and are expected to become an effective tool for the treatment of chronic wounds. This review discusses the methods, mechanisms of action, and challenges associated with the use of PRP-EVs in chronic wound management, providing a foundation for future research and clinical applications in this field.
