Efficacy and safety of ablative fractional carbon dioxide laser combined with dye pulse light and transdermal delivery of triamcinolone acetonide in treatment of keloids
10.3760/cma.j.cn114657-20240201-00014
- VernacularTitle:二氧化碳点阵激光联合窄谱强脉冲激光辅助曲安奈德透皮给药治疗瘢痕疙瘩的疗效和安全性
- Author:
Wenchuan SHEN
1
;
Zhentian WU
1
;
Jun TANG
1
;
Xiao GUO
1
;
Ruohong DING
1
Author Information
1. 黄石市第五医院烧伤整形外科，黄石 435005
- Publication Type:Journal Article
- Keywords:
Keloid;
Ablative fractional carbon dioxide laser;
Dye pulse light;
Triamcinolone acetonide
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(3):237-242
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of transdermal triamcinolone acetonide delivery assisted by carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser in the treatment of keloid.Methods:A total of 82 patients with keloid in the Fifth Hospital of Huangshi City from March 2019 to March 2023 were retrospectively included and divided into two groups according to treatment methods. Combination group: 43 cases, including 20 males and 23 females, aged 20-55 (38.3±7.3) years, with a course of 3-8 (6.2±0.8) months, were treated with carbon dioxide dot matrix laser combined with narrow-spectrum intense pulse laser assisted transdermal administration of triamcinolone. Control group: 39 cases, including 23 males and 16 females, were treated with transdermal administration of triamcinolone acetonide alone, aged 21-54 (37.9±6.5) years, and the course of disease was 3-8 (6.2±0.7) months. Both groups were treated once a month for 9 months. The total effective rate, Vancouver scar scale score, bilateral scar assessment scale score, itching degree of scar, and incidence of adverse reactions were compared between the two groups after 9 months of treatment, and the cumulative recurrence rate of 12 and 24 months after treatment was assessed.Results:The total effective rate of the combined group was 93.0% (40/43), which was higher than that of the control group (76.9%) (30/39, P=0.014). After treatment, the color, vascular distribution, thickness, softness, total score and bidirectional scar assessment scale score of the combined group were lower than those of the control group, and the degree of scar itch was less than that of the control group (all P<0.05). The incidence of adverse reactions was 14.0% (6/43) in the combined group and 17.9% (7/39) in the control group, the difference was not statistically significant ( P=0.621). At 12 months after treatment, the recurrence rate was 4.7% (2/43) in the combination group and 5.1% (2/39) in the control group, with no statistical significance ( P=0.920). At 24 months after treatment, the recurrence rate in the combination group was 7.0% (3/43), lower than that in the control group (23.1%) (9/39, P=0.039). Conclusion:Carbon dioxide dot matrix laser combined with narrow spectrum intense pulse laser assisted transdermal triamcinolone acetonide in the treatment of keloid has a good effect, which can reduce the degree of scar itching, reduce recurrence, and do not increase adverse reactions.
