Effects of oral propranolol on heart rate and blood glucose in children with hemangiomas receiving hospital care
10.3760/cma.j.cn114657-20240421-00057
- VernacularTitle:住院监护下口服普萘洛尔对血管瘤患儿心率和血糖的影响
- Author:
Huaxu HUANG
1
;
Xuanfeng CHEN
;
Beichen CAI
;
Jiaqi YU
;
Bogen XIE
;
Jian CHEN
;
Mingsheng WENG
;
Zhixiong XU
;
Ruilin LI
;
Zheng LU
;
Yongxin HUANG
Author Information
1. 福建医科大学莆田市第一医院教学医院烧伤整形科，莆田 351100
- Publication Type:Journal Article
- Keywords:
Propranolol;
Infantile hemangioma;
Inpatient care;
Heart rate;
Blood glucose;
Adverse reaction
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2025;31(2):120-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of oral propranolol on the heart rate and blood glucose levels in children with hemangiomas receiving hospital care.Methods:A total of 259 children [77 males and 182 females, aged (125.2±85.4) days, weighted (6.3±1.6) kg], who were treated with oral propranolol for the first time under hospital care from January 2013 to August 2021, were retrospectively analyzed. After fasting, the patients administered the same dose of propranolol once daily (0.5-2.5 mg/kg). Fasting blood glucose and heart rate were measured in all children before propranolol administration and after 2 h. Heart rate was measured at 1, 3 and 6 h after propranolol administration for three consecutive days. Adverse reactions were observed and recorded.Results:Within three days of oral propranolol administration, the heart rates at 1, 3 and 6 h after propranolol administration were lower than those before propranolol administration (all P<0.001). Within three days after taking propranolol and 2 h after taking propranolol daily, blood glucose levels reduced in all children (all P<0.001). During the hospitalization period, the incidence of adverse reactions was 5.4% (14/259), including lesion ulcers in four cases, upper respiratory tract infection with fever in four, reduced eating in two, nausea and vomiting in one, lethargy in one, sinus tachycardia in one, and hyperkalemia in one. No serious adverse reactions were life-threatening. Conclusion:After oral administration of propranolol, the heart rate and blood sugar of the children decrease to different degrees compared with those before propranolol administration.
