Ultrasound-regulated bacterial therapy：pioneering a new era of precision cancer immunotherapy
10.3760/cma.j.cn131148-20250807-00419
- VernacularTitle:超声调控细菌疗法：开启精准肿瘤免疫治疗新纪元
- Author:
Yue YUAN
1
;
Beibei ZHANG
;
Shaobo DUAN
;
Yuanyuan LIU
;
Xiaoxiao LI
;
Yanghui LI
;
Lianzhong ZHANG
Author Information
1. 河南省人民医院 郑州大学人民医院超声科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Engineered bacteria;
Cancer immunotherapy;
Bacterial therapy
- From:
Chinese Journal of Ultrasonography
2025;34(11):1007-1012
- CountryChina
- Language:Chinese
-
Abstract:
Although tumor immunotherapy has transformed cancer treatment，its efficacy against solid tumors remains limited by the immunosuppressive tumor microenvironment，inefficient drug delivery，and off-target toxicity. Engineered bacterial therapy has recently attracted considerable interest as a promising therapeutic strategy owing to its capacity for selective tumor colonization and immunomodulation. Meanwhile，ultrasound technology provides a non-invasive，spatially precise，and real-time controllable means to improve the performance and applicability of bacterial-mediated therapies. This review summarizes recent advances in ultrasound-regulated bacterial therapy for cancer immunotherapy. Beginning with an examination of the mechanisms through which engineered bacteria modulate antitumor immunity，it is followed by an elucidation of how ultrasound technology exploits its biological effects and spatiotemporal control capabilities to simultaneously enhance bacterial therapy's safety/efficacy and enable tumor treatment visualization，thereby activating systemic immune responses. Finally，current challenges and future directions for clinical translation are critically discussed. In conclusion，ultrasound-regulated bacterial therapy represents an emerging interdisciplinary approach with the potential to overcome key limitations in solid tumor immunotherapy.
